Cynaropicrin

一种倍半萜内酯；抑制SKOV3、LOX-IMVI、A549、MCF-7、HCT15和PC-3癌细胞的生长（IC50s=1.1-8.7μg/ml）；抑制Huh7.5细胞中的HCV复制（对于基因型1a、1b、2b、3a、4a、5a、6a和7a，EC50s=0.4-1.4μM）；抑制LPS刺激的RAW264.7细胞释放TNF-α和NO（IC50s=8.24和1.1μM）以及LPS诱导的淋巴细胞增殖（IC50=0.9μM）；抑制从感染小鼠中分离的克氏锥虫血流锥虫的生长（EC50=1μg/ml）；对谷粒甲虫、T.confusum幼虫和T.granarium幼虫表现出拒食活性。A sesquiterpene lactone; inhibits the growth of SKOV3, LOX-IMVI, A549, MCF-7, HCT15, and PC-3 cancer cells (IC50s = 1.1-8.7 μg/ml); inhibits HCV replication in Huh7.5 cells (EC50s = 0.4-1.4 μM for genotypes 1a, 1b, 2b, 3a, 4a, 5a, 6a, and 7a); inhibits release of TNF-α and NO from LPS-stimulated RAW264.7 cells (IC50s = 8.24 and 1.1 μM, respectively) as well as LPS-induced lymphocyte proliferation (IC50 = 0.9 μM); inhibits the growth of T. cruzi bloodstream trypomastigotes isolated from infected mice (EC50 = 1 μg/ml); exhibits antifeedant activity against S. granarius beetles, T. confusum larvae, and T. granarium larvae.