(−)-Gallocatechin Gallate

一种具有多种生物活性的多酚；抑制抗EAIgE抗体致敏大鼠腹膜肥大细胞的组胺释放（0.1至1mg/ml）；降低MDA-MB-231乳腺癌细胞（IC50=22μg/ml）和HUVEC的增殖；抑制人胎盘芳香酶活性（IC50=15μM）；溶解克氏锥虫无鞭毛体（MBC50=0.12pM）；降低20μM的RAW264.7破骨细胞生成。A polyphenol with diverse biological activities; inhibits histamine release from anti-EA IgE antibody-sensitized rat peritoneal mast cells from 0.1 to 1 mg/ml; reduces proliferation of MDA-MB-231 breast cancer cells (IC50 = 22 μg/ml) and HUVECs; inhibits human placental aromatase activity (IC50 = 15 μM); lytic against T. cruzi amastigotes (MBC50 = 0.12 pM); decreases RAW 264.7 osteoclastogenesis at 20 μM.