Urocortin III (mouse) (trifluo

一种神经肽激素；在小鼠的下丘脑、脑干和LS/BnST以及小肠、胰腺β细胞和皮肤中表达；选择性地与2型CRF受体结合（对于大鼠CRF2α、大鼠CRF2β和人CRF1，Kis分别为5、1.8和>100nM）；刺激表达大鼠CR2α和小鼠CR2β的CHO细胞中cAMP的产生（EC50s分别为0.073和0.08nM）；增加旷场测试中的探索并减少暗光出现测试中进入光照隔间的潜伏期，表明在小鼠中具有抗焦虑样活性（20μg，icv）；与胰岛素共同释放，以增强野生型小鼠体外和体内葡萄糖刺激的生长抑素释放；在2型糖尿病的小鼠和恒河猴模型中β细胞中耗尽。A neuropeptide hormone; expressed in the hypothalamus, brainstem, and LS/BnST as well as the small intestine, pancreatic β-cells, and skin in mice; selectively binds to type 2 CRF receptors (Kis = 5, 1.8, and >100 nM for rat CRF2α, rat CRF2β, and human CRF1, respectively); stimulates cAMP production in CHO cells expressing rat CR2α and mouse CR2β (EC50s = 0.073 and 0.08 nM, respectively); increases exploration in the open field test and decreases latency to enter the lit compartment in the dark-light emergence test, indicating anxiolytic-like activity in mice (20 μg, i.c.v); co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro and in vivo in wild-type mice; depleted from β-cells in mouse and macaque models of type 2 diabetes.