Umbelliferone

具有多种生物活性的香豆素衍生物和代谢物；浓度为250-300µg/ml时可抑制人类ACHN肾癌、A549肺癌、HCT15结肠癌和LNCaP前列腺癌以及Dakiki骨髓瘤和HL-60淋巴瘤细胞的生长；增加ROS生成并停止KB人类口腔癌细胞的细胞周期；在15和30mg/kg剂量下，对由慢性不可预测的轻度应激诱发的抑郁大鼠模型具有抗抑郁样活性；用作比率pH指示剂，低pH和高pH下ex/em=330和370/460nm。A derivative and metabolite of coumarin with diverse biological activities; inhibits growth of human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells at 250-300 µg/ml; increases ROS production and halts the cell cycle in KB human oral carcinoma cells; has antidepressant-like activity in a rat model of depression induced by chronic unpredictable mild stress at 15 and 30 mg/kg; used as a ratiometric pH indicator with ex/em = 330 and 370/460 nm at low and high pH, respectively.