Atrial Natriuretic Peptide (1-

一种心房利钠肽；与培养的VSMC上的ANP受体结合（Kd=1-2nM）并以剂量依赖性方式增加cGMP；放松钾诱导的犬肾动脉分离带收缩（10和100ng/ml）；扩张麻醉狗的肾动脉（10-100ng/kg）；减少大鼠心力衰竭模型中的心肌细胞大小和心脏纤维化量以及左心室建模。An atrial natriuretic peptide; binds to ANP receptors on culture VSMCs (Kd = 1-2 nM) and increases cGMP dose-dependently; relaxes potassium-induced contraction of isolated canine renal arterial strips (10 and 100 ng/ml); dilates renal arteries in anesthetized dogs (10-100 ng/kg); decreases cardiomyocyte size and the amount of cardiac fibrosis and left ventricular modeling in a rat model of heart failure.