Sulfanilamide

磺胺类抗生素；浓度为20μg/ml时对链球菌有抑菌作用；浓度为0.01%v/v时可抑制106种临床分离的淋球菌的生长；降低感染兔子的血浆链球菌水平；CAII和CAIX的抑制剂（对于人类酶，Kis分别为294和300nM）；对CAII和CAIX的选择性优于CAI和CAIV（对于牛和人类酶，Kis分别为3000和>10,000nM）；浓度为300µM时可抑制溶血性链球菌和大肠杆菌的生长。A sulfonamide antibiotic; bacteriostatic against Streptococcus when at 20 μg/ml; inhibits the growth of 106 clinical isolates of Gonococcus at 0.01% v/v; reduces plasma levels of Streptococcus in infected rabbits; an inhibitor of CAII and CAIX (Kis = 294 and 300 nM, respectively, for the human enzymes); selective for CAII and CAIX over CAI and CAIV (Kis = 3000 and >10,000 nM, respectively, for the bovine and human enzymes); inhibits the growth of S. haemolyticus and E. coli at 300 µM.