HX 1171

一种抗氧化剂；在浓度为10µM和1µM时，在大鼠肝微粒体中可抑制98%和40%的脂质过氧化；通过增强其核转位和转录活性来激活NRF2，从而增加A549人肺上皮细胞中抗氧化相关酶NQO1和HMOX1的表达；在肝硬化大鼠模型中，分别降低肝脏和原代肝细胞中的纤维化和纤维化标志物的水平；降低大鼠模型中肝细胞腺瘤和血管肉瘤的发病率，但增加前胃癌的发病率。An antioxidant; inhibits lipid peroxidation by 98 and 40% when used at concentrations of 10 and 1 µM, respectively, in rat liver microsomes; activates NRF2 by enhancing its nuclear translocation and transcriptional activity, increasing the expression of the antioxidant-related enzymes NQO1 and HMOX1 in A549 human lung epithelial cells; reduces fibrosis and the level of fibrotic markers in liver and primary hepatocytes, respectively, in a rat model of liver cirrhosis; decreases the incidence of hepatocellular adenomas and hemangiosarcomas in a rat model, but increases the incidence of forestomach carcinoma.