Levosimendan

一种钙敏化剂，通过结合肌钙蛋白C（EC50=9nM）引起心脏收缩力增强，通过激活血管平滑肌细胞上的ATP敏感钾通道（EC50=0.28µM）促进血管舒张，并通过促进心肌细胞中线粒体钾通道的开放发挥心脏保护功能；还可抑制磷酸二酯酶3和4（IC50分别为2.5nM和25µM）。A calcium sensitizer that causes increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes; also inhibits phosphodiesterases 3 and 4 (IC50s =2.5 nM and 25 µM, respectively).