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文献和实验Treatment of Infections Caused by Resistant Staphylococcus aureus
up to February 2006. Despite the emergence of resistant and multidrug resistant S. aureus , five effective drugs for which little resistance has been observed are in clinical use: vancomycin, quinupristin-dalfopristin, linezolid, tigecycline, and daptomycin
Treatment of Infections Due to Resistant Staphylococcus aureus
, ceftaroline, and daptomycin. However, vancomycin is less effective for infections with MRSA isolates that have a higher MIC within the susceptible range. Linezolid is probably the drug of choice for the treatment of complicated MRSA skin and soft tissue
研究开发出了一些新型抗生素,如利奈唑胺,初步发现该药与已知抗生素无交叉耐药性,对革兰氏阳性菌特别是对粪屎肠球菌(包括VRE)具有良好的抗菌活性,对MIC90 为4mgL。其它尚有达托霉素(daptomycin)、达福普丁喹奴普丁等,据报道也可用于VRE 的治疗。 5、产Ⅰ型β-内酰胺酶(AmpC 酶)的革兰阴性杆菌 ★产酶菌: 阴沟肠杆菌是最常见的产AmpC 酶细菌,其它革兰氏阴性菌如肺炎克雷伯杆菌、大肠埃希氏菌、铜绿假单胞菌、摩根摩根
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