Ramiprilat

雷米普利的活性代谢物，是一种血管紧张素转换酶(ACE)抑制剂（在人心脏中pKi=9.08），可抑制血管紧张素I转化为血管紧张素II以及缓激肽的降解，从而防止血管收缩；干扰B2激肽受体靶向内皮细胞膜；抑制克罗恩病瘘管中MMP-3和MMP-9的活性。The active metabolite of ramipril, an ACE inhibitor (pKi = 9.08 in human heart) that suppresses the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction; interferes with the targeting of B2 kinin receptors to endothelial cell membranes; inhibits MMP-3 and MMP-9 activity in isolated Crohn's disease fistulas.