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SP-2509

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  • Cayman
  • 2025年07月15日
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    LSD1的可逆抑制剂(IC50=13nM);可增加H3K4甲基化,从而促进培养的AML细胞中p21、p27和CCAAT/增强子结合蛋白α的表达;单独使用可提高生存率,并与帕比司他协同作用,提高植入AML细胞的小鼠的生存率。A reversible inhibitor of LSD1 (IC50 = 13 nM); allows increased methylation of H3K4, driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in cultured AML cells; improves survival alone and synergizes with panobinostat in improving survival of mice engrafted with AML cells.

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