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文献和实验The insulin-like growth factor-binding proteins (IGFBPs) are carrier proteins that are present in all extracellular fluids (1 ). Similarly, insulin-like growth factor-I (IGF-I) and -II are synthesized by connective tissue cells
The binding of ligand to the extracellular domain of the epidermal growth factor (EGF) receptor is the event that initiates the activation of the tyrosine kinase activity present on the cytoplasmic domain. This activation leads
Metronomic PDT and Cell Death Pathways
al. 2004, Photochem Photobiol, 80, 22–30). Metronomic dosing in PDT is proposed by analogy and the rationale is as a means to improve the tumor-specific response through cell death by apoptosis. We investigated the molecular mechanisms associated
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