Nobiletin

一种黄酮类化合物；在25、50和100µM浓度下降低LPS和IFN-γ诱导的RAW264.7细胞中的iNOS蛋白水平和NO生成增加；降低A549、B16/4A5、CCRF-HSB-2和TGBC11TKB癌细胞系的增殖（IC50s分别为22、18、13和8.3µM）；降低以0.3%w/w浓度喂食高脂肪、高胆固醇饮食的小鼠的体重、肝脂肪变性以及血浆LDL和HDL胆固醇水平；抑制同一模型中腹膜内葡萄糖耐量测试中血浆葡萄糖水平的升高。A flavonoid; reduces LPS- and IFN-γ-induced increases in iNOS protein levels and NO production in RAW 264.7 cells at 25, 50, and 100 µM; decreases proliferation of A549, B16/4A5, CCRF-HSB-2, and TGBC11TKB cancer cell lines (IC50s = 22, 18, 13, and 8.3 µM, respectively); reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet at 0.3% w/w; inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.