Prostaglandin E3

Reconstitution of CHIP E3 Ubiquitin Ligase Activity

CHIP, the carboxyl-terminus of Hsp70 interacting protein, is both an E3 ubiquitin ligase and an Hsp70 co-chaperone and is implicated in the degradation of cytosolic quality control and numerous disease substrates. CHIP has been shown

前列腺素（prostaglandin，PG）

　　 广泛存在于哺乳动物和人体的一组重要的活性物质。 1930年，尤勒（ von Enler）发现，人、猴、羊的精液中存在一种使平滑肌兴奋和血压降低的物质，当时设想此物质可能是由前列腺所分泌，命名为前列腺素。但实际上，前列腺分泌物中所含前列腺活性物质不多，为误称。现证明，精液中前列腺素主要来自精囊，并证明前列腺素是内分泌中的一大类。 　　前列腺素的化学本质为具 20个碳原子的不饱和脂肪酸。构成 PG的基本骨架为前列烷酸，具一个环五烷核心和两条侧链。根据五元环或整个

Construction of Mutations in the Adenovirus Early Region 3 (E3) Transcription Units

The E3 transcription unit of the well-studied subgroup C adenoviruses (Ad) (prototypic serotypes 2 [Ad2] and 5 [Ad5]) is located between map units 76–86 ( see Fig. 1 ). The E3 region is surrounded by the genes for virion