Luffariellolide

一种天然二酯萜类化合物，可逆性抑制蜜蜂毒液(IC50=230nM)和蛇毒中的sPLA2同工型，从而减轻炎症；在1μM时，可作为RARα、β和γ的激动剂，但不作为其他核受体的激动剂；抑制缺氧对HIF-1的激活(IC50=3.6μM)A natural sesterterpenoid which reversibly inhibits sPLA2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation; at 1 μM, acts as an agonist for RAR α, β, and γ but not for other nuclear receptors; inhibits the activation of HIF-1 by hypoxia (IC50 = 3.6 μM).