L-Buthionine-(S,R)-Sulfoximine

γ-谷氨酰半胱氨酸合成酶的不可逆抑制剂(Ki=25µM)；抑制ZAZ、M14、A2780和MCF-7癌细胞的增殖(IC50s分别为4.9、18、8.5和26.5µM)；在100µM时诱导A172和T98G胶质母细胞瘤细胞中的铁死亡；在10µM时增加HeLa细胞中的ROS水平；在1mM时与甲基乙二醛结合诱导BAEC凋亡；在给怀孕的母鼠施用2和20nM时增加小鼠幼崽视网膜色素上皮中的眼斑数量；降低胎鼠的半胱氨酸和GSH水平。An irreversible inhibitor of γ-glutamylcysteine synthetase (Ki = 25 µM); inhibits the proliferation of ZAZ, M14, A2780, and MCF-7 cancer cells (IC50s = 4.9, 18, 8.5, and 26.5 µM, respectively); induces ferroptosis in A172 and T98G glioblastoma cells at 100 µM; increases ROS levels in HeLa cells at 10 µM; induces apoptosis of BAECs in combination with methylglyoxal at 1 mM; increases the number of eye spots in the retinal pigment epithelium in mouse pups at 2 and 20 nM when administered to pregnant dams; decreases cysteine and GSH levels in fetal mice.