Caspase-9 (carboxy-terminal di

抗原：对应于大鼠caspase-9氨基酸345-359和366-383的合成肽混合物；宿主：兔；交叉反应性：(+)人、小鼠和大鼠caspase-9；应用：WB；CTD是大鼠caspase-9的一种新型异构体，其中全长caspase-9的C端被替代肽序列取代。它主要存在于细胞质中，在细胞核中未检测到。CTD酶原不在细胞中加工，缺乏凋亡活性。CTD转染细胞对细胞色素c诱导的caspase具有抗性，表明CTD是一种显性负变体。Antigen: mixture of synthetic peptides corresponding to rat caspase-9 amino acids 345-359 and 366-383; Host: rabbit; Cross Reactivity: (+) human, mouse, and rat caspase-9; Application(s): WB; CTD is a novel isoform of rat caspase-9 in which the C-terminus of full-length caspase-9 is replaced with an alternative peptide sequence. It is found primarily in the cytoplasm and was not detected in the nucleus. CTD proenzyme is not processed in the cells and lacks apoptotic activity. The CTD-transfected cells are resistant to caspase induction by cytochrome c, suggesting the CTD acts as a dominant-negative variant.