Salsalate

一种NSAID和水杨酸的前体药物形式；抑制LPS刺激下人体全血中PGE2的产生(IC50=39.9µM)；抑制体重增加，降低空腹血糖和胰岛素水平，以及降低高脂高胆固醇饮食诱发的NASH小鼠模型中的血浆胆固醇和甘油三酯水平（1,000mg/kg）An NSAID and a prodrug form of salicylic acid; inhibits PGE2 production in human whole blood stimulated with LPS (IC50 = 39.9 µM); inhibits weight gain and decreases fasting plasma glucose and insulin levels, as well as decreases plasma cholesterol and triglyceride levels in a mouse model of high-fat high-cholesterol diet-induced NASH at 1,000 mg/kg.