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一种多烯大环内酯,用于治疗白色念珠菌、烟曲霉和寄生L.原生动物引起的感染,以及在组织培养中用于防止真菌污染细胞培养物;与真菌细胞膜中的麦角固醇结合,改变膜通透性并最终诱导细胞死亡A polyene macrolide used in the treatment of infections caused by C. albicans, A. fumigatus, and parasitic L. protozoans, as well as in tissue culture to prevent fungi from contaminating cell cultures; binds with ergosterol in fungal cell membranes, altering membrane permeability and ultimately inducing cell death.
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文献和实验相关实验
Amphotericin B (AmB) is a polyene antibiotic used to treat deep-seated mycoses. Both the pharmaceutical and toxic activities of AmB depend on the molecular organization of the drug. The fluorescence of AmB has proven to be a powerful
and susceptibility against antifungal agents, amphotericin B and fluconazole. We found this technology to be suitable for the detection of Candida cells, for the differentiation between dead and living cells, and for the determination of amphotericin B
化,其他已知细胞松弛素 B还可抑制糖的输送,可以考虑细胞松弛素 B与细胞膜间的相互作用。此外还分离出数种具有类似结构和功能的物质,分别命名为细胞松弛素 A、 C、 D、 E、 F。
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Amphotericin B
¥1





