Obatoclax (mesylate)

Bcl-2家族成员的拮抗剂，含有四个Bcl-2同源域，包括Bcl-2、Bcl-W、Bcl-xL和Mcl-1(Kd~500nM)；可防止这些促存活蛋白与Bax或Bak相互作用，从而诱导细胞凋亡；还可诱导小鼠胚胎成纤维细胞和HeLa细胞中的自噬An antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-xL, and Mcl-1 (Kd ~500 nM); prevents interaction of these pro-survival proteins with Bax or Bak, inducing apoptosis; also induces autophagy in mouse embryo fibroblasts and in HeLa cell.