JMJD2A (human, recombinant; St

来源：在大肠杆菌中表达的重组N端StrepII标记蛋白；Mr：42.7kDa；JMJD2A催化赖氨酸残基9和36处组蛋白三甲基化形式的去甲基化。JMJD2A是一种α-酮戊二酸依赖性Fe(II)加氧酶。通过IMAC纯化Fe依赖性JmjC家族成员会导致催化铁置换并降低活性。因此，该蛋白质通过Strep-Tactin亲和层析纯化。Source: Recombinant N-terminal Strep II-tagged protein expressed in E. coli; Mr: 42.7 kDa; JMJD2A catalyzes the demethylation of trimethylated forms of histone at lysine residues 9 and 36. JMJD2A is an α-ketoglutarate-dependent Fe (II) oxygenase. Purification of Fe-dependent JmjC family members by IMAC can result in displacement of the catalytic iron and decreased activity. Therefore this protein is purified by Strep-Tactin affinity chromatography.