SIRT6 (human, recombinant)

来源：在大肠杆菌中表达的活性重组N端His标记酶氨基酸1-355；Mr：43.7kDa；SIRT6与端粒特异性结合，并在染色质上发挥作用以降低NF-κB信号传导。缺乏SIRT6的哺乳动物细胞显示出异常的端粒结构，类似于在沃纳综合征中发现的缺陷，沃纳综合征是一种与寿命缩短有关的过早衰老疾病。Source: Active recombinant N-terminal His-tagged enzyme amino acids 1-355 expressed in E. coli; Mr: 43.7 kDa; SIRT6 associates specifically with telomeres and functions at chromatin to decrease NF-κB signaling. Mammalian cells depleted of SIRT6 display abnormal telomere structures similar to defects found in Werner syndrome, a premature aging disorder associated with a shortened life span.