BAY 60-7550

一种强效且选择性高的PDE2抑制剂（IC50分别为牛和人类酶2 nM和4.7 nM）；对PDE2比PDE1具有50倍的选择性，并且对PDE5、PDE3B、PDE4B、PDE7B、PDE8A、PDE9A、PDE10A和PDE11A的选择性大于100倍；通过在小鼠体内以3 mg/kg剂量增加cGMP信号，拮抗氧化应激引起的焦虑样行为；以1 mg/kg剂量提高大鼠在物体定位任务中的表现，并增强cAMP/cGMP介导的物体记忆和空间记忆的巩固。A potent and selective PDE2 inhibitor (IC50s = 2 and 4.7 nM for the bovine and human enzymes, respectively); 50-fold selective for PDE2 over PDE1 and >100-fold selective over PDE5 PDE3B, PDE4B, PDE7B, PDE8A, PDE9A, PDE10A, and PDE11A; antagonizes oxidative stress-induced anxiety-like behavioral effects in mice by increasing cGMP signaling at 3 mg/kg; improves the performance of rats in an object location task and enhances cAMP/cGMP-mediated object and spatial memory consolidation at 1 mg/kg.