Prostaglandin A1

PGA1首次作为PGE1化合物在人体精液中的脱水产物被分离出来。研究表明，它可以引起肾脏血管扩张，增加尿钠排泄，并降低高血压患者的动脉压。它还对肿瘤细胞具有抑制生长的活性；在人类卵巢癌抑制中的IC50值为7.5 µM。 PGA1 was first isolated as a dehydration product of the PGE1 compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 µM.