D-myo-Inositol-1,3,4,5,6-penta

肌醇磷酸(InsP)家族的一种成员，属于小型可溶性第二信使；抑制Akt/PKB的磷酸化和激酶活性，诱导卵巢癌、肺癌和乳腺癌细胞凋亡；表现出抗血管生成活性以及抗肿瘤作用；与Grp1的PH结构域结合，Kd为590nM。A member of the inositol phosphate (InsP) family of small, soluble second messengers; inhibits the phosphorylation and kinase activity of Akt/PKB, inducing apoptosis in ovarian, lung, and breast cancer cells; exhibits antiangiogenic activity as well as antitumor effects; binds to the PH domain of Grp1 with a Kd of 590 nM.