CREB (Phospho-Ser133) Transcri

CREB（cAMP反应元件结合蛋白）是一种转录因子，可与cAMP反应元件(CRE)启动子位点结合，以调节参与代谢调节、抑郁、长期记忆和其他生理过程的众多基因的转录。丝氨酸133(Ser133)上的磷酸化可激活CREB，从而诱导靶基因的转录。生长因子、神经递质、缺氧、生长因子、紫外线、生存信号和应激信号等各种刺激是已知的CREB激活剂。Cayman的CREB（磷酸化Ser133）转录因子检测是一种非放射性、灵敏的方法，用于检测核提取物或全细胞裂解物中的CREBDNA结合活性。CREB (cAMP-response-element-binding protein) is a transcription factor that binds to cAMP-responsive element (CRE) promoter sites to regulate the transcription of numerous genes involved in metabolic regulation, depression, long term memory, and other physiological processes. Phosphorylation on serine 133 (Ser133) activates CREB to induce transcription of target genes. Diverse stimuli such as growth factors, neurotransmitters, hypoxia, growth factors, UV light, survival signals, and stress signals are some of the known activators of CREB. Cayman's CREB (Phospho-Ser133) Transcription Factor Assay is a non-radioactive, sensitive method for detecting CREB DNA binding activity in nuclear extracts or whole cell lysates.