5(S),6(R)-11-trans DiHETE

5(S),6(R)-11-trans DiHETE是5(S),6(R)-DiHETE的C-11双键异构体，通过膜结合因子催化5(S),6(R)-DiHETE的酶促异构化形成。5(S),6(R)-11-trans DiHETE已在大鼠肾脏匀浆中发现，可能通过环氧化酶水解途径在该组织中形成。负责将LTB4转化为6-trans LTB4的大鼠肾脏匀浆中的异构酶活性也与其形成有关。5(S),6(R)-11-trans DiHETE不是大豆脂氧合酶的底物。关于5(S),6(R)-11-trans DiHETE的生物学活性尚未有报道。5(S),6(R)-11-trans DiHETE is a C-11 double bond isomer of 5(S),6(R)-DiHETE that is formed by the enzymatic isomerization of 5(S),6(R)-DiHETE by a membrane bound factor. 5(S),6(R)-11-trans DiHETE has been found in rat kidney homogenates and is potentially formed by the epoxide hydrolase pathway in this tissue. The isomerase activity responsible for the conversion of LTB4 to 6-trans LTB4 in rat kidney homogenates has also been implicated in its formation. 5(S),6(R)-11-trans DiHETE is not a substrate for soybean lipoxygenase. The biological activity of 5(S),6(R)-11-trans DiHETE has not been reported.