Raf-1 (Phospho-Ser642) Polyclo

抗原：与大鼠raf-1磷酸化Ser642周围氨基酸残基相对应的磷酸肽；宿主：兔；交叉反应性：(+)大鼠raf-1；预计会与牛、犬、鸡、人、小鼠、非人灵长类动物和非洲爪蟾raf-1发生反应；应用：WB；Raf丝氨酸/苏氨酸激酶家族成员的功能是将信号从活化的Ras传递到下游蛋白激酶MEK和ERK，这对细胞增殖、分化、存活和致癌转化至关重要。RAf-1活性受Ser301和Ser642磷酸化的调节。Antigen: phosphopeptide corresponding to amino acid residues surrounding phospho-Ser642 of rat raf-1; Host: rabbit; Cross Reactivity: (+) rat raf-1; expected to react with bovine, canine, chicken, human, mouse, non-human primate, and Xenopus raf-1; Application(s): WB; Members of the Raf serine/threonine kinase family function to relay signals from activated Ras to the downstream protein kinases MEK and ERK, which are critical for cellular proliferation, differentiation, survival, and oncogenic transformation. RAf-1 activity is regulated by phophorylation of Ser301 and Ser642.