Phorbol 12-myristate 13-acetat

一种PKC激活剂；在报告基因检测中以1-10ng/ml的浓度诱导NF-κB依赖性基因表达；促进THP-1单核细胞分化为促炎性巨噬细胞，并在体外诱导NETs的形成；与DMBA联合促进大鼠皮肤致癌两阶段模型中的乳头状瘤形成。A PKC activator; induces NF-κB-dependent gene expression in a reporter assay at 1-10 ng/ml; promotes the differentiation of THP-1 monocytes into pro-inflammatory macrophages, as well as induces the formation of NETs, in vitro; promotes papilloma formation in a rat two-stage model of skin carcinogenesis in combination with DMBA.