GFAP (human) EIA Kit

GFAP是一种40-53kDa的单体分子，仅在中枢神经系统（CNS）的成人胶质细胞中发现，是星形胶质细胞细胞骨架的主要组成部分。成人CNS的创伤性损伤会引发胶质细胞的快速炎症反应，主要表现为胶质细胞的肥大、增殖和GFAP表达增加，导致胶质病。因此，GFAP被认为是监测发育和病理条件下神经元活动的可靠细胞特异性生物标志物，可用于脑损伤和视网膜应激等病理监测。GFAP（人类）EIA基于双抗体夹心技术，可用于测量人类样本中的GFAP，如血清、血浆、培养上清液和脑脊液。GFAP is a 40-53 kDa monomeric molecule found only in adult glial cells of the central nervous system (CNS) and represents the major part of the cytoskeleton of astrocytes. Traumatic injury to the adult CNS results in a rapid inflammatory response by the resident astrocytes, characterized mainly by hypertrophy, proliferation (of astrocytes), and increased GFAP expression, resulting in astrogliosis. Thus, GFAP is considered to be a reliable cell-specific biomarker for monitoring neuronal activity under developmental and pathological conditions, such as brain injury, and retinal stress. The GFAP (human) EIA is based on a double-antibody sandwich technique and can be used to measure GFAP in human samples such as serum, plasma, culture supernatant, and cerebrospinal fluid.