Capsazepine

TRPV1的竞争性拮抗剂，阻断新生大鼠背根神经节（IC50=0.42µM）和中国仓鼠卵巢细胞（IC50=17nM）中辣椒素诱导的Ca2+摄取；不阻断酸或热诱导的TRPV1激活，可能阻断除TRPV1以外的其他受体。A competitive antagonist of TRPV1 which blocks the capsaicin-induced uptake of Ca2+ in neonatal rat dorsal root ganglia (IC50 = 0.42 µM) and Chinese hamster ovary cells (IC50 = 17 nM); does not block acid- or heat-induced activation of TRPV1 and may block receptors other than TRPV1.