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文献和实验DNA-Dependent Protein Kinase in Apoptosis
target proteins, one of which is the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs). The antiapoptotic factor Bcl-xL can sequester cytochrome C and inhibit the formation of the caspase-9-Apaf-1 complex effectively blocking apoptosis
Utilizing Peptide SPOT Arrays to Identify Protein Interactions
., Langeberg, L.K., Fayos, R., Jennings, P.A., and Scott, J.D. 2003. Bioinformatic design of A‐kinase anchoring protein‐in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring. Proc. Natl. Acad. Sci. U.S.A. 100:4445‐4450
Specificity Profiling of Protein‐Binding Domains Using One‐Bead‐One‐Compound Peptide Libraries
without the need for any special equipment, and therefore can be employed in any chemical or biochemical laboratory. OBOC peptide libraries have been widely used to map the ligand specificity of proteins, to determine the substrate specificity of enzymes, and to develop inhibitors
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