Hesperetin

具有多种生物活性的黄酮类化合物；减少HepG2细胞中ApoB蛋白水平、ACAT2表达和LDL降解（浓度范围：10-200µM）；抑制IgG诱导的β-六氨基葡萄糖苷酶释放（IC50=0.099mg/ml）；抑制LPS诱导的NO产生，并减少BV-2小胶质细胞中的iNOS、IL-6和IL-1β水平；在小鼠模型中抑制被动皮肤过敏反应（剂量为5mg/kg）；在TNBS诱导的溃疡性结肠炎小鼠模型中减少体重损失、结肠缩短和溃疡严重性；在LPS诱导的神经炎症小鼠模型中，减少皮质和海马神经元凋亡，增加在目标象限的时间。A flavonoid with diverse biological activities; reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells from 10-200 µM; inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC50 = 0.099 mg/ml); inhibits LPS-induced NO production and reduces levels of iNOS, IL-6, and IL-1β in BV-2 microglial cells; inhibits passive cutaneous anaphylaxis in mice at 5 mg/kg; reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis; reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.