Matairesinol

一种具有多种生物活性的木脂素；减少LPS诱导的RAW264.7细胞中NO和PGE2的产生；对结肠26癌细胞具有细胞毒性（LC50=9µg/ml）；以100µM的浓度延长秀丽隐杆线虫的寿命；在0.4、2和10µM浓度下减少奥沙利铂诱导的PC12神经细胞神经毒性；局部给药在尘螨诱导的小鼠特应性皮炎模型中减少耳朵增厚、肥大细胞浸润及血清IgE水平，剂量为50µg/耳。A lignan with diverse biological activities; reduces LPS-induced production of NO and PGE2 in RAW 264.7 cells; cytotoxic to colon 26 cancer cells (LC50 = 9 µg/ml); increases the lifespan of C. elegans at 100 µM; reduces oxaliplatin-induced neurotoxicity in neural PC12 cells at 0.4, 2, and 10 µM; topical administration reduces ear thickness and mast cell infiltration, as well as serum IgE levels, in a mouse model of dust mite-induced atopic dermatitis at 50 µg/ear.