Reversine

嘌呤衍生物；根据细胞类型诱导分化或去分化；抑制AuroraA、B和C激酶，IC50值为98-876nM；A3受体拮抗剂(Ki=0.66µM)；抑制MPS1（其激酶结构域和全长版本的IC50分别为6和2.8nM）；诱导WRO人滤泡性甲状腺癌细胞自噬；降低Akt/mTOR信号传导。A purine derivative; induces differentiation or dedifferentiation, depending on cell type; inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM; A3 receptor antagonist (Ki = 0.66 µM); inhibits MPS1 (IC50s = 6 and 2.8 nM for its kinase domain and full-length version, respectively); induces autophagy in WRO human follicular thyroid cancer cells; decreases Akt/mTOR signaling.