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新冠假病毒（SARS-CoV-
2 Pseudotyped virus）和中和抗体筛选评价体系-疫苗及抗体开发必备
企业认证
SARS-CoV-2(2019nCoV) Pseudotyped virus production and Pseudotyped Virus Based Neutralization Assay
-20冻存
新冠SARS-CoV-2假病毒及Spike蛋白突变株（D614G, S943P, V367F, G476S,
V483A, H49Y, Q239K, A831V, P1263L, D839Y/N/E: D839Y, D839N, D839E）
药诺基因提供的新冠SARS-CoV-2假病毒（GM-2019nCoV-PSV01~PSV13）是含有Spike蛋白的慢病毒颗粒，用于模拟SARS-CoV-2感染细胞和细胞侵入。
SARS-CoV-2假病毒颗粒基因组编码荧光素酶（Firefly Luciferase）和红色荧光蛋白（RFP）。在SARS-CoV-2假病毒进入表达ACE2的细胞后，Firefly Luciferase和RFP则会强表达。
人源 ACE2过表达的HEK293T稳转细胞系通常被用来作为效应细胞(GM-SC-293T-hACE2-01。
药诺基因提供的新冠SARS-CoV-2假病毒可用于SARS-CoV-2相关疫苗的疗效评估，中和抗体，多肽阻断剂竞争中和试验，还有组织特异性感染测定等。
| Catalog No. | Pseudotyped virus of SARS-CoV-2 Spike Mutation Variants and Effector cells |
| GM-2019nCoV-PSV01-2 | SARS-CoV-2 Pseudotyped virus packaging and production |
| GM-SC-293T‐hACE2-01 | Human ACE2 overexpression stable HEK293T cell lines |
| GM-2019nCoV-PSV02 | Spike D614G mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV03 | Spike S943P mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV04 | Spike V367F mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV05 | Spike G476S mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV06 | Spike V483A mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV07 | Spike H49Y mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV08 | Spike Q239K mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV09 | Spike A831V mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV10 | Spike P1263L mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV11 | Spike D839Y/N/E-D839Y mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV12 | Spike D839Y/N/E-D839N mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV13 | Spike D839Y/N/E-D839E mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV14 | P2-mutated Spike protein trimer variant (P2-mutant, S1/S2 cleavage site (furin cleavage sequence)-mutant, (trimerization modified) mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV15 | Spike of SARS-COV-2 B.1.1.7 lineage mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV16 | Spike(S1+S2) N501Y mutation SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV17 | Spike(S1+S2)-HV 69-70 Deletion mutation(ΔH69/ΔV70) SARS-CoV-2(2019nCoV) Pseudotyped virus |
| GM-2019nCoV-PSV18 | Spike(S1+S2)-E484K mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (501Y.V2 lineage) |
| GM-2019nCoV-PSV19 | Spike (S1+S2) RBD triple mutation(K417N, E484K and N501Y) of SARS-CoV-2(2019nCoV) Pseudotyped virus (501Y.V2 lineage) |
| GM-2019nCoV-PSV20 | Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) 501Y.V2 lineage Pseudotyped virus |
| GM-2019nCoV-PSV21 | Spike (S1+S2) RBD triple mutation(K417T, E484K and N501Y)+D614G of SARS-CoV-2(2019nCoV) Pseudotyped virus (Brazilian P.1 lineage) |
| GM-2019nCoV-PSV22 | Spike whole mutant SARS-CoV-2(2019nCoV) Brazilian P.1 lineage Pseudotyped virus |
| GM-2019nCoV-PSV23 | Spike(S1+S2) RBD-S477N mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (B.1.526 lineage; 20A.EU2 lineage) and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV24 | Spike (S1+S2) RBD mutation (S477N)+ D253G of SARS-CoV-2(2019nCoV) Pseudotyped virus (B.1.526 lineage) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV25 | Spike (S1+S2) RBD mutation (E484K)+ D253G of SARS-CoV-2(2019nCoV) Pseudotyped virus (B.1.526 lineage) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV26 | Spike whole mutant SARS-CoV-2(2019nCoV) B.1.526 lineage Pseudotyped virus production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV27 | Spike(S1+S2) RBD-E484Q mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India)) and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV28 | Spike (S1+S2) RBD mutation L452R of SARS-CoV-2(2019nCoV) Pseudotyped virus (double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India)) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV29 | Spike (S1+S2) RBD mutation (E484Q+L452R) of SARS-CoV-2(2019nCoV) Pseudotyped virus (double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India)) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV30 | Spike whole mutant SARS-CoV-2(2019nCoV) double mutant variant EPI_ISL_1360318, S:E484Q+L452R (India) Pseudotyped virus production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV31 | Spike(S1+S2) RBD-S477G mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (B.1.526 lineage) and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV32 | Spike(S1+S2) RBD-T478K mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (delta variant B.1.617.2 lineage) and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV33 | Spike (S1+S2) RBD mutation (L452R+T478K) of SARS-CoV-2(2019nCoV) Pseudotyped virus (delta variant B.1.617.2 lineage) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV34 | Spike whole mutant SARS-CoV-2(2019nCoV) delta variant B.1.617.2 lineage Pseudotyped virus production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV35 | Spike (S1+S2) RBD mutation L452Q of SARS-CoV-2(2019nCoV) Pseudotyped virus (lambda variant C.37 lineage) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV36 | Spike(S1+S2) RBD mutation F490S of SARS-CoV-2(2019nCoV) Pseudotyped virus (lambda variant C.37 lineage) and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV37 | Spike (S1+S2) RBD mutation (L452Q+F490S) of SARS-CoV-2(2019nCoV) Pseudotyped virus (lambda variant C.37 lineage) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV38 | Spike whole mutant SARS-CoV-2(2019nCoV) lambda variant C.37 lineage Pseudotyped virus production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV39 | Spike RBD mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (Omicron variant aka B.1.1.529) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV40 | Spike whole mutant SARS-CoV-2(2019nCoV)Omicron variant aka B.1.1.529 Pseudotyped virus production and Pseudovirus Based Neutralization Assay |
| Spike Mutation in SARS-COV-2 (2019nCOV) Omicron variant aka B.1.1.529 lineage | Spike-S1 Subunit N Terminal | A67V | |
| Δ69-70 | |||
| T95I | |||
| G142D | |||
| Δ143-145 | |||
| Δ211-212 | |||
| ins214EPE | |||
| Spike-RBD | G339D | Important residues mutation Important residues mutation | |
| S371L | |||
| S373P | |||
| S375F | |||
| K417N | |||
| N440K | |||
| G446S | |||
| S477N | |||
| T478K | |||
| E484A | |||
| Q493R | |||
| G496S | |||
| Q498R | |||
| N501Y | |||
| Y505H | |||
| Spike-S1 Subunit | T547K | ||
| D614G | A popular mutation in different new SARS-CoV-2 lineage | ||
| H655Y | |||
| N679K | |||
| P681H | |||
| Spike-S2 Subunit | N764K | ||
| D796Y | |||
| N856K | |||
| Q954H | |||
| N969K | |||
| L981F |
| Cat No. | Pseudotyped virus of SARS-CoV-2 Spike Mutation Variants |
| GM-2019nCoV-PSV39 | Spike RBD mutation of SARS-CoV-2(2019nCoV) Pseudotyped virus (Omicron variant aka B.1.1.529) production and Pseudovirus Based Neutralization Assay |
| GM-2019nCoV-PSV40 | Spike whole mutant SARS-CoV-2(2019nCoV)Omicron variant aka B.1.1.529 Pseudotyped virus production and Pseudovirus Based Neutralization Assay |
| Cat No. | Antigen Name of 2019-nCoV(SARS-CoV-2) | Source (Expression Host) |
| GMP-V-2019nCoV-Mpro001 | Recombinant 2019nCoV antigen-coronavirus Main Proteinase (Mpro, 3CLpro, His Tag) | E.coli |
| Cat No. | Neutralizing antibody Name | Source (Expression Host) |
| GMP-V-2019nCoV-SnAb006 | Anti-2019-nCoV Spike (Spike RBD domain) human monoclonal neutralizing antibody (IgG1) | Mammalian (human cell) |
| GMP-V-2019nCoV-SnAb007 | Anti-2019-nCoV Spike (Spike RBD domain) human monoclonal neutralizing antibody (IgG1) | Mammalian (human cell) |
| GMP-V-2019nCoV-SnAb008 | Anti-2019-nCoV Spike (Spike RBD domain) human monoclonal neutralizing antibody (IgG1) | Mammalian (human cell) |
| Cat No. | Antigen Name of 2019-nCoV(SARS-CoV-2) | Source (Expression Host) |
| GMP-V-2019nCoV-Smu-027 | Recombinant 2019-nCoV(SARS-CoV-2) Spike Protein RBD mutant (Omicron variant aka B.1.1.529) | Mammalian (human cell) |
| GMP-V-2019nCoV-S-trimer-004 | Recombinant 2019-nCoV(SARS-CoV-2) Spike S-trimer Protein (Omicron variant aka B.1.1.529 lineage) with furin cleavage site mutation & T4 fibritin trimerization motif | Mammalian (human cell) |
| GMP-H-ACE2001 | Recombinant human solubale ACE2 protein (soluble hACE2,extracellular hACE2,C-His) | Mammalian (human cell) |
| GMP-H-ACE2002 | Recombinant human solubale ACE2 protein (soluble hACE2,extracellular hACE2,C-FC) | Mammalian (human cell) |
| Cat No. | Gene &Vector description of 2019 nCoV | Vector | Tag | Coden Optimized |
| GMV-V-2019nCoV-192 | pGM-Spike RBD mutation of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529 | pcDNA3.1(+) | No tag | coden optimized for mamamlian |
| GMV-V-2019nCoV-193 | Ad-Spike RBD mutation of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529 | Pre-made adenovirus | C-3FLAG | coden optimized for mamamlian |
| GMV-V-2019nCoV-194 | pGMLV-Spike RBD mutation of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529 | Lentiviral vector | C-3FLAG | coden optimized for mamamlian |
| GMV-V-2019nCoV-195 | pGM-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529 | pcDNA3.1(+) | No tag | coden optimized for mamamlian |
| GMV-V-2019nCoV-196 | Ad-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529 | Pre-made adenovirus | C-3FLAG | coden optimized for mamamlian |
| GMV-V-2019nCoV-197 | pGMLV-Spike (S1+S2) whole mutation variant of SARS-CoV-2(2019nCoV) Omicron variant aka B.1.1.529 | Lentiviral vector | C-3FLAG | coden optimized for mamamlian |
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