【rSDF 1a】重组大鼠基质细胞衍生因子-1α/【rSDF

产品名称：【rSDF 1a】重组大鼠基质细胞衍生因子-1α-Recombinant Rat Stromal Cell-Derived Factor-1 alpha （CXCL12）

产品货号：CHM-354

产品规格：10ug///1mg///2ug

来源宿主：大肠杆菌中重组表达

保存建议：【rSDF 1a】重组大鼠基质细胞衍生因子-1α-Recombinant Rat Stromal Cell-Derived Factor-1 alpha （CXCL12）大鼠基质细胞衍生因子-1α（rSDF 1a）冻干粉末在室温可保存3周，或置于-18℃冻存用于长期保存.重新溶解后可以在4℃冷藏保存至少2-7天；如果想延长保存时间，建议分装（加载体蛋白如0.1% HSA或 BSA）后置于-18℃冻存.请避免反复冻融.

背景资料：SDF-1 （stromal cell-derived factor-1） is small cytokine belonging to the chemokine family that is officially designated Chemokine （C-X-C motif） ligand 12 （CXCL12）. It is produced in two forms， SDF-1?/CXCL12a and SDF-1?/CXCL12b， by alternate splicing of the same gene. Chemokines are characterized by the presence of four conserved cysteines， which form two disulfide bonds. The CXCL12 proteins belong to the group of CXC chemokines， whose initial pair of cysteines are separated by one intervening amino acid. CXCL12 is strongly chemotactic for lymphocytes and has been implicated as an important cell co-ordinator during development. During embryogenesis it directs the migration of hematopoietic cells from foetal liver to bone marrow. Mice which were knocked-out for CXCL12 gene were lethal before the birth or within just 1 hour of life. As another role， CXCL12a alters also the electrophysiology of neurons. CXCL12 was shown to be expressend in many tissues in mice （including brain， thymus， heart， lung， liver， kidney， spleen and bone marrow）.The receptor for this chemokine is CXCR4， which was previously called fusin. This CXCL12-CXCR4 interaction used to be considered exclusive （unlike for other chemokines and their receptors）， but recently it was suggested that CXCL12 is also bound by CXCR7 receptor.The gene for CXCL12 is located on human chromosome 10. In human and mouse both CXCL12 and CXCR4 show high identity of sequence: 99% and 90%， respectively.

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关键词：Recombinant Rat Stromal Cell-Derived Factor-1 alpha （CXCL12），【rSDF 1a】重组大鼠基质细胞衍生因子-1α，SDF 1a