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- 详细信息
- 文献和实验
- 技术资料
- 库存：
999
- 英文名：
Acteoside
- CAS号：
61276-17-3
- 保质期：
详见产品说明
- 供应商：
仕诺达生物
- 保存条件：
-20度
- 规格：
20mg；分析标准品98% (多规格选择）/200mg；分析标准品
| 规格： | 20mg；分析标准品98% (多规格选择） | 产品价格： | ￥450.0 |
|---|---|---|---|
| 规格： | 200mg；分析标准品 | 产品价格： | ￥2500.0 |
| 中文名 | 毛蕊花糖苷 |
| 英文名 | acteoside |
| 别名 | 阿克苷 麦角甾苷 毛蕊花苷 毛蕊花糖苷 类叶升麻苷 麦角甾苷(毛蕊花糖苷) 麦角甾苷, 来源于肉苁蓉 类叶升麻苷,毛蕊花糖苷(标准品) 毛蕊花糖苷(麦角甾苷,阿克苷,类叶升麻苷) |
| 英文别名 | Acetoside acteoside verbascoside Verbascoside VERBASCOSIDE WITH HPLC 3,4-Dihydroxyphenethyl alcohol acteoside Extract from Verbena minutiflora (B864379) glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxyhexopyranosyl)-4-O-[3-(3,4-dihydroxyphenyl)acryloyl]hexopyranoside 2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate] 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-alpha-L-mannopyranosyl)-4-O-[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]-beta-D-glucopyranoside [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate |
| CAS | 61276-17-3 |
| 化学式 | C29H36O15 |
| 分子量 | 624.59 |
| InChI | InChI=1/C29H36O15/c1-13-22(36)23(37)24(38)29(41-13)44-27-25(39)28(40-9-8-15-3-6-17(32)19(34)11-15)42-20(12-30)26(27)43-21(35)7-4-14-2-5-16(31)18(33)10-14/h2-7,10-11,13,20,22-34,36-39H,8-9,12H2,1H3/b7-4+/t13-,20+,22-,23+,24+,25+,26+,27+,28+,29-/m0/s1 |
| InChIKey | FBSKJMQYURKNSU-ZLSOWSIRSA-N |
| 密度 | 1.60±0.1 g/cm3(Predicted) |
| 熔点 | 232℃ |
| 沸点 | 908.8±65.0 °C(Predicted) |
| 比旋光度 | (c, 1.15 in MeOH)-84.9 |
| 闪点 | 294.7°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | DMSO (微溶)，乙酸乙酯 (非常微溶)，甲醇 (微溶) |
| 折射率 | 1.689 |
| 酸度系数 | 9.31±0.10(Predicted) |
| 存储条件 | Sealed in dry,Room Temperature |
| 稳定性 | 吸湿性 |
| 外观 | 固体 |
| 颜色 | White to Pale Yellow |
| 物化性质 | 类白色或淡黄色结晶粉末，溶于甲醇，来源于大芸（硬质肉苁蓉发黑含量最高0.47%）大叶紫珠、车前子、地黄、肉苁蓉、紫竹叶。 |
| MDL号 | MFCD00221751 |
| 体外研究 | Verbascoside acts as an ATP-competitive inhibitor of PKC, with an IC 50 of 25 µM. Verbascoside shows K i s of 22 and 28 µM with respect to ATP and histone, respectively. Verbascoside has potent antitumor activity against L-1210 cells, with an IC 50 of 13 µM. Verbascoside (5, 10 µM) suppresses 2,4-dinitrochlorobenzene (DNCB)-induced T cell costimulatory factors CD86 and CD54, proinflammatory cytokines, and NFκB pathway activation in THP-1 cells. |
| 体内研究 | Verbascoside (1%) reduces the overall scratching behavior incidence as well as the severity of the skin lesions in 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) mice model. Verbascoside also blocks DNCB-induced expression of proinflammatory cytokine TNF-α, IL-6, and IL-4 mRNA in skin lesions. Verbascoside (50, 100 mg/kg, i.p.) does not modify chronic constriction injury (CCI)-induced cold allodynia. Verbascoside (200 mg/kg, i.p.) decreases hyper-sensitivity to cold stimulus, actone, on day 3 in rats. Verbascoside also significantly reduces behavioral changes associated with neuropathy. Moreover, Verbascoside decreases Bax and increases Bcl-2 on day 3. |
计算化学数据：
- 分子量：624.58714g/mol
- 化合物是否规范：True
- 疏水参数计算参考值（XLogP3-AA）：-0.5
- 准确质量：624.20542044
- 同位素质量：624.20542044
- 复杂度：936
- 可旋转化学键数量：11
- 氢键供体数量：9
- 氢键受体计数：15
- 拓扑极表面积：245
- 重原子数量：44
- 确定原子立构中心数量：10
- 不确定原子立构中心数量：0
- 确定化学键立构中心数量：1
- 不确定化学键立构中心数量：0
- 同位素原子计数：0
- 共价键单元数量：1
- CACTVS Substructure Key Fingerprint：AAADcfB4PAAAAAAAAAAAAAAAAAAAAAAAAAA0aIEAAAAAAAABQAAAGgAACAAADBSwmAMyDoAABgCIAiDSCAACAAAgIAAIiAAGiMgZNiKCMRKicAElwBEPuYfA4LwOIAABAAAAQABAAAIAAACAAAAAAAAAAA==
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17-酮甾类（酮类固醇） 17-ketosteroid，17 oxosteroid
甾类骨架上第 17位碳原子上的氧基的化合物之总称，缩写 17KS。在生物体内，是由 17位羟基的酶促氧化和 C17 -C20 键切断生成的。在尿中含有来自副肾皮质的去氢表雄酮及其硫酸酯，睾丸酮的代谢物雄酮和表雄酮等。雌酮也以 17-酮甾类的形态存在着。因为副肾皮质和卵巢肿瘤患者的尿中的排出量很高，所以可作为临床的诊断指标。又因 17-酮甾类在碱性间 -硝基苯溶液中呈紫色，所以可进行定量测定。
C18 H24 O2 雌甾 -1， 3， 5（ 10） -三烯 -3， 17-二醇。系代表性的性激素，可用卵巢、胎盘等制备，在卵泡液、胎盘、妊娠马尿中均可检出。进入子宫上皮细胞后，与性激素受体形成复合体进入细胞核，从而促进新的蛋白质合成，具有引起细胞增殖的作用。此外，能影响未成熟或切除卵巢的大鼠或小鼠的阴道分泌物，使呈现由角化细胞组成的显微镜象，所以也用作生物试验。在生物体内，在 17β -羟甾类脱氢酶的作用下氧化成为雌酮。 17α -羟甾体性激素的作用弱。作为女性
甾类（化合物）17α-羟化酶 steroid 17α－hy- droxylase，s eroid 17α-monooxygeoase
甾类（化合物）17α-羟化酶 steroid 17α－hy- droxylase，s eroid 17α-monooxygeoase 存在于睾丸、肾上腺的微粒体部分。是一种在甾类分子的17α位置上引入羟基的酶。EC1、14、99、9。需要有分子态氧和NADPH存在，与P－450有关。例如将黄体酮和孕（甾）烯醇酮各自成为17α-羟基黄体酮和17α-羟基孕烯醇酮。在鼠的肾上腺中不存在此酶。
