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- 详细信息
- 文献和实验
- 技术资料
- 免疫原:
KLH-conjugated synthetic peptide
- 形态:
Liquid
- 保存条件:
Store lyophilized/reconstituted at -20°C; once rec
- 克隆性:
Polyclonal
- 适应物种:
Human
- 抗原来源:
P16104
- 级别:
分子生物学级
- 供应商:
Agrisera
- 宿主:
Rabbit
- 应用范围:
1: 10 000 (Dot), 1: 10 000 (ELISA), 1: 1000 (WB)
- 靶点:
Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. H2A.XS139p appears during apoptosis and is probably involved in DNA repair.
- 抗体英文名:
Antibody is present in PBS with 0.05 % sodium azide and 0.05% ProClin 300.
- 抗体名:
H2A.XS139p | H2A.X phosphorylated serine 139
- 规格:
50 µg
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文献和实验Using the scan‐x Web Site to Predict Protein Post‐Translational Modifications
spectrometry data is providing evidence that almost every protein in the cell undergoes some form of post?translational modification. We describe a protocol to use the scan?x Web site to view predicted acetylation sites in the human proteome and predicted
的 相互作用,并充当效应蛋白的平台,导致下游级联事件。 磷酸化发生在所有核心组蛋白上,并且对每一个核心组蛋白都有不同的作用。组蛋白 H3 在丝氨酸 10 和 28 上的磷酸化,以及组蛋白 H2A 在 T120 上的磷酸化参与了染色质致密化以及有丝分裂过程中 染色质结构和功能的调节。这些是细胞周期和细胞生长的重要标志,在真核生物中得以保留。S139 处 H2AX 的磷酸化(产生 γH2AX)作为 DNA 损伤修复蛋白的招募点 (Lowndes et al., 2005, Pinto et al
Histone H2AX Phosphorylation: A Marker for DNA Damage
) are generated that rapidly result in the phosphorylation of histone H2A variant H2AX. Because phosphorylation of H2AX at Ser 139 (γ-H2AX) is abundant, fast, and correlates well with each DSB, it is the most sensitive marker that can be used to examine the DNA
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