Dnmt1|Dnmt1蛋白|Dnmt1小鼠蛋白|Dnmt1

A method for purification, identification and validation of DNMT1 mRNA binding proteins

DNA methyltransferase 1 (DNMT1) is the enzyme responsible for the maintenance of DNA methylation patterns during cell division. DNMT1 expression is tightly regulated within the cell cycle. Our previous study showed that the binding of a protein

三句话读懂一篇 CNS：人造蛋白质药物再获突破；每天喝 2～3 杯咖啡，或降低心脏病风险

免疫疗法，使前列腺癌患者的生存率增加！ 图 3：来源 Nature 4. Nature：人工设计蛋白质药物再获突破 抗体蛋白药物在治疗癌症等疾病中立下了汗马功劳，然而其制造难度和稳定性限制了临床应用。 2022 年 3 月 24 日，美国华盛顿大学蛋白设计研究所 David Baker 教授团队在 Nature 杂志发表研究论文 Design of protein binding proteins from target structure alone。 该研究针对癌症生长

microRNA参与狼疮低甲基化调控机制

indirectly downregulated DNMT1 expression by targeting an important autoimmune gene, RASGRP1, which mediated the Ras–MAPK pathway upstream of DNMT1; miR-148a directly downregulated DNMT1 expression by targeting the protein coding region of its transcript