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MedChemExpress LLC
- CAS号:
173459-90-0
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询盘
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PEG4-sulfonic acid
CAS No. : 173459-90-0
MCE 国际站:PEG4-sulfonic acid
产品活性:PEG4-sulfonic acid 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。
研究领域:PROTAC
作用靶点:PROTAC Linkers
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
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文献和实验The pathogenesis of the inflammatory bowel diseases (IBD), which include ulcerative colitis and Crohn’s disease, is still not fully understood. It is likely that proinflammatory cytokine release and derangement of the immune response play
: a)氯(-),由胶缓冲液提供,充当快速移动的先导离子。b)MES或MOPS(-),(取决于电泳缓冲液的选择)充当后随离子。MES: 2-(N-morpholino)ethane sulfonic acidMOPS: 3-(N-morpholino)propane sulfonic acidc)Bis-Tris碱(+)充当出现在胶中的共同离子,Tris(+)由电泳缓冲液提供。合并低pH值的胶缓冲液(pH6.4)和电泳缓冲液(pH7.3-7.7)导致了电泳时显著降低的工作pH值。图2 NuPAGE®
Buffer (0.28 M TES (free acid), 0.12 M HCl, 0.05 M DTT, 0.08 M MgCl2 , 0.2 M NaCl), TES = N-tris [hydroxymethyl]methyl-2-aminoethane sulfonic acid, MW 229.2 Stop solution 1 N NaOH (freshly prepared from 10 N Stock) [35 S]dATP (1000 Ci / mmol
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