NMDA in CA1 hippocampus H96

In Vitro and In Vivo Recording of Local Field Potential Oscillations in Mouse Hippocampus

(arrow) into a shallow vessel containing ice‐cold cutting solution and gently bubble with carbogen. Repeat A through F on the second brain hemisphere. (G ) Use a large spatula to lift the hippocampus from the cutting solution. CA1/CA3 should be facing

Water Maze Testing to Identify Compounds for Cognitive Enhancement

., Michael, T.H., and Rose, G.M. 2002. Theta‐frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats. J. Neurosci. 22:9932‐9940.   

快速老化痴呆模型小白鼠SAMP8, SAMP10老化特征及其相关研究进展

,早期可见伴有大量的和广泛的星形细胞增生。另外，空泡性变化在8个月时其峰值下落，至老龄则不明显[8,9]。⑵ 海马锥体细胞的树状棘密度的减少Golgi染色和组织定量研究表明，P8海马锥体细胞树突棘的密度发生了明显的异常变化，与对照组R1相比，CA1和CA3 棘的密度明显减少，并有统计学意义。说明进入该部位的锥体细胞突触减少。考虑到海马是记忆的重要结构，因此P8的学习记忆障碍与此异常具有直接关系[10]。⑶ 随加龄出现明显的星形细胞增生P8发育早期即出现星形细胞的增生。应用 GFAP 染色观察