- ￥924 - 3988
- MedChemExpress(MCE)
- 美国
- HY-135953
- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1883650-95-0
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥924.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2475.0 |
| 规格： | 10 mg | 产品价格： | ￥3988.0 |
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CDDO-3P-Im
CAS No. : 1883650-95-0
MCE 国际站：CDDO-3P-Im
产品活性：CDDO-3P-Im 是 CDDO 咪唑胺类似物，具有化学预防作用。CDDO-3P-Im 可降低小鼠肺癌模型肺肿瘤的大小和严重程度。CDDO-3P-Im 是一种具有口服活性的坏死 (necroptosis) 抑制剂，可用于缺血/再灌注 (I/R) 的研究。
研究领域：Apoptosis
作用靶点：Apoptosis
In Vitro: CDDO-3P-Im (30-100 nM; 4 days) induces differentiation of U937 cells at 30 nM.
CDDO-3P-Im suppresses NO production in RAW264.7 cells with an IC50 of 4.3 nM.
In Vivo: CDDO-3P-Im is more stable than CDDO-Im in pharmacokinetic studies.
CDDO-3P-Im significantly elevates heme oxygenase-1 (HO-1) and quinone reductase (NQO1) mRNA and protein levels in various mouse tissues in vivo.
CDDO-3P-Im (50-200 mg/kg; diet; for 16 weeks) decreases the number, the size and the severity of tumors in A/J mice.
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文献和实验9ZttBbJQ8joJWDztq26nnX7ayYN9mjCn0yV7ZDph9jDDz9s3/6Xf7HNG9bbeWfPsyeeeMq14xDkgggycwdLMlPJYQISQ0TgTUYgkuQ3GfBYXEQgIhARiAjsvwg0RXqZfQYxnTXjOHvw/gfsEZlHVFl9T5R1hzxKfOpTn9Jsu7oNaS/65LmG0uAfGBvc6UfOsB/95GprbWsXYa7bPbI1Pu7oY6xPGuRTTjvdvviXf23jxo2zYcOG2nhpYq/68Y
xUmkC2lYqiGzBHnh9eRvmrvsApdKT0a1Y6P+rlN4j7p8JxEaAhY/YyPB1uQkEvDuCrfeCUXp2RxTRoNDQ9fqhrsYwXNh6Be712iHseFpIIUH4hGN7fmHhwXvYS+EJnm8bjj7LZqDttcJoP+847FobI+TZdozptRQzp9RDvUNdJUFCRVUJgXiHHXMuYdyq03hYXhvuNy0wdsQSDJxsiEsbm0Eo95XoS08YNqbnYlavniR8XKMvz+hfrCm5LqEx+Pbtm6Rx+fLli2SP4e3
Molecular Modeling of Nucleic Acid Structure: Electrostatics and Solvation
., Petrella, R.J., Roux, B., Won, Y., Archontis, G., Bartels, C., Boresch, S., Caflisch, A., Caves, L., Cui, Q., Dinner, A.R., Feig, M., Fischer, S., Gao, J., Hodoscek, M., Im, W., Kuczera, K., Lazaridis, T., Ma, J., Ovchinnikov, V., Paci, E., Pastor, R.W
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