20-羟基二十烷酸甲酯|Methyl 20-hydroxye

20-羟基二十烷酸甲酯，Methyl 20-hydroxyeicosanoate，Methyl 20-hydroxyeicosanoate

产品名称：20-羟基二十烷酸甲酯-Methyl 20-hydroxyeicosanoate

产品货号：1878-25

产品规格：25mg

背景资料：This product is a high purity omega-hydroxy very long chain fatty acid methyl ester that is ideal as a standard and for biological studies. Omega-oxidation is a minor fatty acid pathway used for fatty acid metabolism and usually occurs in the smooth endoplasmic reticulum. Eicosanoic acid is enzymaticaly converted to the 20-hydroxyeicosanoic acid as well as to the eicosadicarboxylic acid as part of the omega-oxidation metabolic pathway. Stimulation of omega-hydroxylation has been proposed as a method for treating X-linked adrenoleukodystrophy, a disease that is characterized by elevated levels of very long chain fatty acids.1 Omega-hydroxy fatty acids have an important role acylated to various lipids. Omega-hydroxylated very long chain fatty acid (VLCFA) ceramides are vital to skin barrier functions and a deficiency of these lipids can cause death from water loss through the skin. A mutation in an elongase enzyme for VLCFA results in a deficiency in omegahydroxylated VLCFA-ceramides which causes a muscular dystrophy disease, defective skin-water permeability barrier function, and neurological disorders showing the importance of these VLCFA ceramides.2 Sphingolipids (such as sphingomyelin, ceramides, and glucosylceramides) acylated with polyunsaturated and alpha- or omega-hydroxylated VLCFA have been found in the spermatozoa/testes and in the epidermis. Sphingolipids with VLCFA may be responsible for the maturation of these cell.3

保存建议：20-羟基二十烷酸甲酯-Methyl 20-hydroxyeicosanoate对于本产品，我们推荐使用常温进行运输。在您收到货物后，我们建议在22℃（常温）保存，溶解使用说明请参考本品说明。

产品描述：omega-Hydroxy C20:0 methyl ester

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