N-己酰基-生物素-植物鞘氨醇|N-Hexanoyl-bio

N-己酰基-生物素-植物鞘氨醇，N-Hexanoyl-biotin-phytosphingosine，N-Hexanoyl-biotin-phytosphingosine

产品名称：N-己酰基-生物素-植物鞘氨醇-N-Hexanoyl-biotin-phytosphingosine

产品货号：2211-5

产品规格：5mg

背景资料：This phytoceramide analogue contains a biotin unit attached to the amine of the phytosphingosine moiety via a hexanoic acid linker and is ideal for use in sphingolipid studies. The biotin structure allows for attachment of the ceramide to streptavidin and avidin making it extremely useful for binding to substrates and for toxin detection1. Phytosphingosine is a long-chain sphingoid base having important cellular functions such as signaling, cytoskeletal structure, cellular cycle, and heat stress response. It is found largely in mammals, plants, and yeast. Phytosphingosine has seen much use in cosmetics due to its effects on the skin such as reducing inflammation by inhibiting the expression of the allergic cytokines IL-4 and TNF-α and the activation of the transcription factors NF-jB and c-jun in histamine-stimulated skin tissues.2 Phytosphingosine can lead to apoptosis via two distinct pathways and has been investigated as a possible cancer therapeutic treatment. Phytoceramides (fatty acid acylated to Phytosphingosine) are distributed at the microvillous membrane of the epithelial cells of the small intestine. Crypt cells and the adjacent epithelial cells produce phytosphingoglycolipids in much greater quantities than more differentiated epithelial cells.3 The kidney and skin also contain phytosphingoglycolipids although in much lower concentrations than in the small intestine. Phytoceramides form part of the water barrier lipids of the skin. 2-hydroxytetracosanoyl-phytoceramide has recently been shown to have immunostimulating effects in humans.4 Phytoceramides have lately been studied in regards to their role in the central nervous system and have been found to have important functions in neuroprotection.5

保存建议：N-己酰基-生物素-植物鞘氨醇-N-Hexanoyl-biotin-phytosphingosine对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明。

产品描述：N-C6:0-biotin-Phytoceramide

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