Tomatidine盐酸番茄碱,6192-62-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Tomatidine hydrochloride

CAS No. : 6192-62-7

MCE 国际站：Tomatidine hydrochloride

产品活性：Tomatidine hydrochloride 通过阻断 NF-κB 和 JNK 信号发挥抗炎作用。Tomatidine hydrochloride 激活哺乳动物细胞或秀丽隐杆线虫中的自噬 (autophagy)。

研究领域：NF-κB  |  MAPK/ERK Pathway  |  Autophagy

作用靶点：NF-κB  |  JNK  |  Autophagy

结构分类：甾体类

来源：植物  |  茄科  |  番茄

In Vitro: Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.

相关产品：Covalent Screening Library Plus  |  Natural Product Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Metabolism/Protease Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Natural Product Library  |  Autophagy Compound Library  |  Anti-Aging Compound Library  |  Covalent Screening Library  |  Antioxidant Compound Library  |  Differentiation Inducing Compound Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Anti-Cardiovascular Disease Compound Library  |  Pyroptosis Compound Library  |  Alkaloids Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Anti-Obesity Compound Library  |  Transcription Factor-Targeted Library  |  Food-Sourced Compound Library   |  Anti-Liver Cancer Compound Library   |  Antidepressant Compound Library  |  Phorbol 12-myristate 13-acetate  |  Bortezomib  |  SP600125  |  TAK-243  |  Pyrrolidinedithiocarbamate ammonium  |  JSH-23  |  Anisomycin  |  Shikonin  |  Sulfasalazine  |  Triptolide  |  JNK-IN-8  |  Dihydroartemisinin  |  Baicalin  |  Rocaglamide  |  BAY 11-7085  |  Betulinic acid  |  Parthenolide  |  Astragaloside IV  |  SN50  |  5-Aminosalicylic Acid  |  QNZ  |  (-)-DHMEQ  |  Guggulsterone  |  NIK SMI1  |  B022  |  Caffeic acid phenethyl ester  |  Tanzisertib  |  Lidocaine  |  Andrographolide  |  20(S)-Ginsenoside Rg3

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  染料试剂  |  PROTAC  |  同位素标记物  |  寡核苷酸

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种TOP期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪前沿的制药及生命科学研究进展，为您提供全球前沿的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。