Mupirocin calcium hydrate

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Mupirocin calcium hydrate

CAS No. : 115074-43-6

MCE 国际站：Mupirocin calcium hydrate

产品活性：Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate 可从 Pseudomonas fluorescens 中分离得到，是一种有口服活性的抗生素。Mupirocin calcium hydrate 通过可逆地抑制异亮氨酸转移 RNA，从而抑制细菌蛋白和 RNA 的合成而发挥抗菌作用。

研究领域：Anti-infection

作用靶点：Bacterial  |  Antibiotic

In Vitro: Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate (0-100 μM; 48 h) shows antibacterial effect against staphylococci, streptococci and certain gram-negative bacteria, with MIC values range from 0.06-0.25 μg/mL (MIC₅₀ =0.12 μg/mL, MIC₉₀ =0.25 μg/mL).
Mupirocin calcium hydrate is highly bound (95% bound) to human serum protein, thus results in activity inhibition in the presence of human serum.
Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.
Mupirocin calcium hydrate (2% ointment) reduces pro-inflammatory cytokines IL-1β and IL-17 level, decreases tumor necrosis factor-alpha (TNF-α) expression, and increases the leavel of vascular endothelial growth factor (VEGF).
Mupirocin calcium hydrate inhibits MS (S. epidermidis ATCC 12228), MR (S. epidermidis (Se56-99)), and VIR (S. epidermidis (Se43-98)) with MICs of 0.25, 1.26, 1.59 mg/L.
Note: MIC, the minimum inhibition concentration.

In Vivo: MRSA: Meticillin-resistant Staphylococcus aureus
Mupirocin (BRL-4910A, Pseudomonic acid) calcium is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A.
Mupirocin calcium (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment.
Mupirocin calcium (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice.
Mupirocin calcium (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis.

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