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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
Pure form: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
1670249-37-2
- 规格:
25 mg/50 mg/100 mg/250 mg/500 mg/1 g
| 规格: | 25 mg | 产品价格: | ¥220.0 |
|---|---|---|---|
| 规格: | 50 mg | 产品价格: | ¥350.0 |
| 规格: | 100 mg | 产品价格: | ¥500.0 |
| 规格: | 250 mg | 产品价格: | ¥665.0 |
| 规格: | 500 mg | 产品价格: | ¥1321.0 |
| 规格: | 1 g | 产品价格: | ¥1676.0 |
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Azido-PEG9-acid
CAS No. : 1670249-37-2
MCE 国际站:Azido-PEG9-acid
产品活性:Azido-PEG9-acid 是一种不可降解 (non-cleavable) 的含 9 个单元 PEG 的 ADC linker,可用于合成抗体偶联活性分子 (ADC)。Azido-PEG9-acid 是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。Azido-PEG9-acid 是一种点击化学试剂。它含有 Azide 基团,可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应(CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。
研究领域:PROTAC | Antibody-drug Conjugate/ADC Related
作用靶点:PROTAC Linkers | ADC Linker
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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文献和实验Purification of Plasmid from 50 ml-culture
of cold 70% ethanol. Discard the fluid. 14. Add to the pellet 400 ul of TE containing DNase-free RNase A (20 ug/ml). Incubate the tube for 30 min at 37 C. 15. After 30 min, carefully check the content of the tube. If nucleic acid pellet
potassium acetate add 150 ml glacial acetic acid and bring up to 1 liter with Q store at 4 ℃ 2、PEG 8000 40% PEG 8,000 40 g PEG 8,000 up to 100 ml with Q store at room temperature 3、Procedure • Spin down 5 ml of a overnight culture in 3 eppendorf
as needed Solution III 25% potassium acetate 250 g potassium acetate add 150 ml glacial acetic acid and bring up to 1 liter with Q store at 4 ℃ 2、PEG 8000 40% PEG 8,000 40 g PEG 8,000 up to 100 ml with Q store at room temperature
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