Maleimido-tri(ethylene glycol)

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Maleimido-tri(ethylene glycol)-propionic acid

CAS No. : 518044-40-1

MCE 国际站：Maleimido-tri(ethylene glycol)-propionic acid

产品活性：Maleimido-tri(ethylene glycol)-propionic acid 是一种可降解 (cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。Maleimido-tri(ethylene glycol)-propionic acid 用于 neolymphostin 为基础的 ADC 前体的制备，用于位点特异性半胱氨酸突变体曲妥珠单抗- A114C 的偶联。Maleimido-tri(ethylene glycol)-propionic acid 也可以用作基于 PEG 的 PROTAC Linker，可用于合成PROTAC。

研究领域：Antibody-drug Conjugate/ADC Related  |  PROTAC

作用靶点：ADC Linker  |  PROTAC Linkers

In Vitro: Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7.
ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively.
ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC₅₀ of 195 and 202 nM, respectively.
ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC₅₀ of 286 and 274 nM, respectively.

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