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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
-20°C, stored under nitrogen
- 库存:
货期:1-2天
- 供应商:
MedChemExpress LLC
- CAS号:
2055014-94-1
- 规格:
100 mg/250 mg/1 g/5 g
| 规格: | 100 mg | 产品价格: | ¥296.0 |
|---|---|---|---|
| 规格: | 250 mg | 产品价格: | ¥504.0 |
| 规格: | 1 g | 产品价格: | ¥1326.0 |
| 规格: | 5 g | 产品价格: | ¥4858.0 |
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Propargyl-PEG8-acid
CAS No. : 2055014-94-1
MCE 国际站:Propargyl-PEG8-acid
产品活性:Propargyl-PEG8-acid 是一种 PROTAC 连接桥,属于 PEG 类。Propargyl-PEG8-acid 可用于合成一系列 PROTAC 分子。Propargyl-PEG8-acid 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体活性分子结合物 (ADCs) 的合成。这些 ADCs 可用于革兰氏阴性细菌引起的细菌感染。Propargyl-PEG8-acid 是一种点击化学试剂。它含有 Alkyne 基团,可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。
研究领域:Antibody-drug Conjugate/ADC Related | PROTAC | Anti-infection
作用靶点:ADC Linker | PROTAC Linkers | Bacterial
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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文献和实验, 2.2M dNTP’s 100mM EDTA 0.5M EtBr 10mg/ml Gelatin 2% Glucose 1; 1.5; 2M Guanidine HCl 1-8M HEPES 1M Imidazol 2M Paraformaldehyde 37% PEG 40% PMSF 100mM Retinoic acid 10mM Sucrose 1; 2; 2.5M Tris Cl 1M
Table of Contents 10X TBE 40% Acrylamide Stock Alkaline lysis solution 10X TBE: 216 g Tris base 110 g boric acid 16.6 g EDTA Add water to 2 liters. 40% Acrylamide/Bisacrylamide (40% A&B): 38 g Acrylamide (Kodak 5521) 2 g N,N
Microinjecting worms by Michael Koelle 8/23/94 You will have a couple frustrating sessions when you first attempt this technique, but everyone seems to master injection
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